| ncRNA name | hsa-pre-miR-3135b |
| ncRNA Category | miRNA |
| Disease name | age-related macular degeneration (AMD) |
| Species | Homo sapiens |
| Tissues/Cell_line | RPE cells (ARPE), brain samples |
| Methods | qPCR, TaqMan miRNA assay, luciferase reporter assay, Western blot |
| Expression pattern | associated |
| Functional description | We identified three variants in miRNAs significantly associated with AMD. rs4351242, is located in the terminal loop region of miR-3135b.Reduced expression levels of miR-3135b in rs41275792 minor allele carriers may result in increasing C3 expression and alter the risk of AMD. |
| PubMed ID | 28397307 |
| Year | 2017 |
| Title | Genetic variants in microRNAs and their binding sites within gene 3'UTRs associate with susceptibility to age-related macular degeneration. |
| Drug-related ncRNA | NO |
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